Table 2. Kaplan-Meier method and Cox proportional hazards model analysis of associations between the genotypes of XPG and CRC prognosis.
Variants | 10 years OS | 10 years PFS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
event | Median (months) | Log-rank P | HR (95% CI) | P a | event | Median (months) | Log-rank P | HR (95%CI) | P b | |
rs2094258 | ||||||||||
TT | 83 | 106.067 | 1.000 | 76 | 87.667 | 1.000 | ||||
CT | 254 | 21.267 | 0.357 | 0.973 (0.747, 1.268) | 0.842 | 208 | 98.633 | 0.169 | 0.85 (0.655, 1.108) | 0.232 |
CC | 265 | 119.800 | 0.945 | 0.942 (0.724, 1.223) | 0.649 | 227 | 83.967 | 0.728 | 1.019 (0.785, 1.323) | 0.889 |
CT/CC | 519 | 119.800 | 0.600 | 0.978 (0.865, 1.106) | 0.722 | 435 | 92.033 | 0.363 | 0.964 (0.854, 1.090) | 0.561 |
rs2296147 | ||||||||||
CC | 25 | 20.067 | 1.000 | 18 | 118.067 | 1.000 | ||||
CT | 200 | 119.800 | 0.392 | 1.381 (0.837, 2.276) | 0.206 | 178 | 84.867 | 0.024 | 1.780 (1.093, 2.898) | 0.021 |
TT | 377 | 119.867 | 0.258 | 1.492 (0.915, 2.433) | 0.108 | 315 | 89.567 | 0.025 | 1.740 (1.080, 2.803) | 0.023 |
CT/TT | 577 | 119.800 | 0.267 | 1.205(0.946,1.535) | 0.131 | 493 | 88.500 | 0.020 | 1.324 (1.046, 1.667) | 0.020 |
rs751402 | ||||||||||
AA | 83 | 119.867 | 1.000 | 76 | 83.867 | 1.000 | ||||
AG | 263 | 119.800 | 0.489 | 0.953 (0.733, 1.240) | 0.721 | 216 | 89.133 | 0.384 | 0.851 (0.655, 1.107) | 0.851 |
GG | 256 | 117.800 | 0.567 | 0.893 (0.688, 1.161) | 0.399 | 219 | 92.033 | 0.521 | 0.830 (0.639, 1.080) | 0.830 |
AG/GG | 519 | 119.800 | 0.478 | 0.960 (0.850, 1.085) | 0.515 | 435 | 91.233 | 0.414 | 0.917 (0.811, 1.036) | 0.165 |
rs873601 | ||||||||||
AA | 155 | 117.800 | 1.000 | 144 | 85.300 | 1.000 | ||||
AG | 286 | 119.800 | 0.347 | 1.028 (0,831, 1.272) | 0.799 | 227 | 92.900 | 0.119 | 0.856 (0.694, 1.056) | 0.856 |
GG | 161 | 119.867 | 0.822 | 0.994 (0.780, 1.267) | 0.964 | 140 | 93.267 | 0.502 | 0.969 (0.766, 1.226) | 0.969 |
AG/GG | 447 | 119.800 | 0.574 | 1.008 (0.912, 1.113) | 0.877 | 367 | 93.267 | 0.162 | 0.946 (0.859, 1.043) | 0.265 |
CRC, colorectal cancer; HR, hazard ratio; CI, confidence interval; OS, overall survival; PFS, progression-free survival.
P values were calculated after adjustment for BMI, dukes stage, recurrence/metastasis status and therapeutic response.
P values were calculated after adjustment for age and dukes stage.