Table 1.

Neuroimaging study subject characteristics and survival to dementia predictors stratified by age in a multivariate cox model

Age at baseline	79.8 (4.1)	n = 106
Gender F:M	57:49
Deceased during follow-up	60 (57%)
Developed dementia during follow-up	27 (25%)
MMSE	26.2 (2.7)
CAMCOG-R	84.4 (8.5)
MTA	2.7 (1.8)
White matter hyperintensity, ml	2.1 (1.8)
Total brain volume	1009 (82.4)
Oxford Stroke Classification (LACS/PACS/TACS/POCS/unknown)	35/42/5/17/7
	HR (95% CI)	P -value
Significant neuroimaging predictor
MTA	1.40 (1.07 to 1.85)	0.016
Log (frontal white matter hyperintensities / total brain volume)	1.88 (1.05 to 3.36)	0.034
AIREN bilateral thalamic lesions	9.18 (2.36 to 35.63)	0.001
Significant neuroimaging predictor + cognitive score
MTA	1.32 (1.00 to 1.74)	0.054
Log (frontal white matter hyperintensities / total brain volume)	1.68 (0.92 to 3.05)	0.09
AIREN bilateral thalamic lesions	4.58 (1.19 to 17.70)	0.027
CAMCOG-R	0.93 (0.89 to 0.98)	0.004

Oxford community stroke project (OCSP) classification: there were no significant differences between stroke territory distributions between PSND and PSD cases ( P > 0.05). CAMCOG = Cambridge Assessment for mental and cognition; LACS = lacunar stroke; na = not available; PACS = partial anterior circulation stroke; POCS = posterior circulation stroke; TACS = total anterior circulation stroke; AIREN = relevant imaging change meets imaging criteria as specified in the National Institute of Neurological Disorders and Stroke Association/Internationale pour la Recherche et al. rsquo; Enseignement en Neurosciences (NINDS/AIREN) criteria; CAMCOG-R = Cambridge Cognitive Assessment-revised; GDS = Geriatric Depression 15 point scale; MTA = medial temporal lobe atrophy rating; MMSE = Mini-Mental State Examination; TIA = transient ischaemic attack.