Figure 5.

Suppression of ptr-6 by mboa-1, an ACAT homolog. (A) mboa-1 is a homolog of ACAT, which produces cholesteryl ester using cholesterol and acyl CoA as substrates. (B) mboa-1 RNAi suppresses the ptr-6 ethanol-resistant phenotype. (C) mboa-1 overexpression in the wild-type background causes ethanol resistance. (D) Representative images of cholesteryl ester staining in wild-type and ptr-6 mutant animals. The intensity of images was measured from the hypodermis or intestine. White rectangles highlight the staining signals from the hypodermis and white circles highlight signals from the intestine. (E) Quantitative analysis of the staining results. ***P < 0.001. *P < 0.05. Bars, 150 μm.