Table 2. Validation of deletions that impair fitness of multiple disomes.

Gene	Rank	Disome I	Disome V	Disome IX	Disome XI	Disome XIV	Disome II	Disome XIII	Disome XVI	Disome XII	Disome VIII	Disome XV
FLO1	1	NE	ND	ND	NE	ND	ND	ND	NE	ND	NE	ND
SHE3	3	NE	ND	NE	NE	ND	NA	NE	NE	ND	NE	ND
UBP3*	11	NE	NA	NE	−−	−−	−−	NE	−−	−−	−	−−
SNX41	12	ND	ND	−	NE	ND	ND	ND	NE	ND	−	ND
TSA2	15	NE	ND	NE	NE	ND	ND	NE	NE	ND	NE	ND
CYM1	30	NE	ND	NE	NE	ND	ND	ND	NE	ND	NE	ND
PPN1*	43	−	NE	−	−−	−−	NE	−	−	NE	−	−
TPS1*	48	−	ND*	−−	−−	NE	NA	−−	−−	−	NE	NE
SIR1	111	ND	NE	NE	NE	ND	ND	NE	NE	ND	NE	ND
MNN10*	115	NE	−	−	−−	ND*	NE	−−	−−	−−	−	−−
RVS167*	152	−−	−−	−−	−−	−	NE	NE	−	ND*	−	NE

–, negative synthetic effect; – –, strong negative synthetic effect; NE, no effect; ND*, no data because this strain was found to have lost its extra chromosome in at least one case; ND, no data; NA, gene on disomic chromosome so not tested. (*) indicates confirmed gene deletions with synthetic negative fitness interactions across disomic strains.