Skip to main content
. Author manuscript; available in PMC: 2016 Jun 13.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2016 Feb 24;51(3):162–184. doi: 10.3109/10409238.2016.1143913

Figure 2.

Figure 2

PP2A biogenesis and holoenzyme assembly is regulated by unique factors. α4 protects inactive PP2Ac from ubiquitination by MID1. Activating metal ions are loaded by PTPA, and active PP2Ac binds to the scaffold subunit (A). The C-terminal tail of PP2Ac can be methylated by LCMT-1 and reversed by PME-1. Active, methylated PP2A-AC can then form holoenzymes with one B subunit. These available B subunits are divided into four families: B, B′, B″ and B‴, each with unique characteristics and regulation. (see colour version of this figure at www.informahealthcare.com/bmg).