Table 2.

PP2A-interacting proteins identified by literature and database searches. Reviews, Pubmed and Biogrid (Chatr-Aryamontri et al., 2015) results are presented.

Interacting proteins	B subunit	PhosphoSite	Interaction boundary	References
ADCY8	–	–	–	(Crossthwaite et al., 2006)
ADRA1A	–	–	–	(Krueger et al., 1997)
AKAP9	PR130	–	–	(Takahashi et al., 1999)
AKT	Bα	T308	–	(Kuo et al., 2008)
APC	B′, B‴	bCatenin, -	302–625, 188–774	(Breitman et al., 2008, Galea et al., 2001)
AP1M1	Bα	T156	–	(Ricotta et al., 2008)
APP	B′γ, B′ε	–	–	(Olah et al., 2011)
AR	–	–	–	(Yang et al., 2007)
ARL2	Bα	–	–	(Shern et al., 2003)
ATM	–	S1981	2427–2841	(Goodarzi et al., 2004)
ATR	–	–	–	(Kim et al., 1999)
ATXN7L2	PR72	–	–	(Lim et al., 2006)
AURKA	–	S51	46–56	(Horn et al., 2007)
AXIN1	B′α	–	595–726	(Arnold et al., 2009, Yamamoto et al., 2001)
BANF1-ANKLE4	Bα	–	59–938	(Asencio et al., 2012)
ARRB2	–	–	–	(Beaulieu et al., 2005)
BAX	–	S184	–	(Xin & Deng, 2006)
BAZ	B′	S1085	–	(Krahn et al., 2009)
BCL2	B′γ	T69, S70, S87	–	(Lin et al., 2006), (Ruvolo et al., 2008)
BEST1	–	–	–	(Marmorstein et al., 2002)
BLNK	Bγ	–	–	(Oellerich et al., 2011)
BRCA1	B′γ	–	–	(Woods et al., 2012)
BUBR1	B′	–	630–720	(Xu et al., 2013)
CACNA1C	Bα, Bβ, PR70	S1928	1927–2029	(Hall et al., 2006)
CACNA1S	Bα	–	–	(Kristensen et al., 2012)
CAPN1	–	–	–	(Hall et al., 2006)
CAMK4	–	–	–	(Westphal et al., 1998)
CAMK2B	–	T253	–	(Hoffmann et al., 2005)
CPD	–	–	–	(Varlamov et al., 2001)
CAS	–	–	–	(Yokoyama & Miller, 2001)
CASP3	–	–	–	(Alvarado-Kristensson & Andersson, 2005)
CBX1	–	–	–	(Nozawa et al., 2010)
CCNG1	B′α	–	–	(Okamoto et al., 1996,2002)
CCNG2	B′β, B′γ	–	–	(Bennin et al., 2002)
CCT2	Bγ	–	–	(Glatter et al., 2009)
CDCA2 (repoman)	B′α	S893	586–595	(Qian et al., 2013)
CDC25	B′	T138	–	(Lammer et al., 1998, Margolis et al., 2003,2006a,b)
CDC6	PR70	S54/S74	49–90	(Davis et al., 2008, Petersen et al., 1999, Wlodarchak et al., 2013)
CDH1 (e-cadherin)	–	–	–	(Gotz et al., 2000)
CDK16	Bα	–	–	(Varjosalo et al., 2013a)
CDK 4	–	–	–	(Sablina et al., 2007)
CDK5R1	B′δ	–	–	(Louis et al., 2011)
CDK9	–	–	–	(Ammosova et al., 2005)
CFTR	–	–	–	(Vastiau et al., 2005)
CHEK1	–	S317 & S345	–	(Leung-Pineda et al., 2006)
CIP2A	–	–	–	(Junttila et al., 2007)
CFL1	–	–	–	(Samstag & Nebl, 2003)
GJA1	–	–	–	(Kanemitsu et al., 1998, Meilleur et al., 2007)
CSNK1E	–	–	–	(Varjosalo et al., 2013b)
CTLA4	B′α	–	151–159	(Baroja et al., 2002)
CTNNB1 (β-Catenin)	B′, Bα	S33, S37, T41, S45, S552, S675	APC, Mult.	(Seeling et al., 1999, Zhang et al., 2009)
CUL3	B′β	–	315–374	(Bennett et al., 2010, Oberg et al., 2012)
CXCR2	–	–	–	(Fan et al., 2001)
DARPP32	PR72	T75	–	(Ahn et al., 2007b)
DLG4	B′δ	–	–	(Arbuckle et al., 2010)
DNML1/DRP1	Bβ2	S656	–	(Merrill et al., 2013)
E4orf3 [adenovirus]	–	–	–	(Shtrichman et al., 1999)
EGFR	PR130, B′ε	–	–	(Foerster et al., 2013, Zwaenepoel et al., 2010)
EIF1AK2	B′α	–	–	(Xu & Williams, 2000)
EIF4EBP1	Bα	–	–	(Bishop et al., 2006)
ELAVL1	B′ε	–	–	(Abdelmohsen et al., 2009)
ERAL1	–	S18	–	(Keen et al., 2005)
ETF1	–	–	–	(Lechward et al., 1999)
ERK1/ERK2	B′β, B′γ	T202/T185	IEK-1	(Letourneux et al., 2006)
ESPL1 (separase)	B′α-ε	–	1419–1474	(Holland et al., 2007)
FAM107A	Bα	–	–	(Ewing et al., 2007)
FBXO43	–	–	319–375	(Wu et al., 2007)
FMRP	–	–	–	(Narayanan et al., 2007)
GNA12	–	–	–	(Zhu et al., 2004)
GNB2L1	–	–	138–317	(Kiely et al., 2006)
GRIA1	–	–	–	(Mao et al., 2005)
GRB2	Bα	–	–	(Bisson et al., 2011)
GRIN2A	–	–	–	(Chan & Sucher, 2001)
GRK5	Bα	–	–	(Wu et al., 2012)
GSK3B	B′δ	S9	–	(Liu & Eisenman, 2012)
H2AX	–	–	–	(Chowdhury et al., 2005)
HAND1	B′δ	–	150–216	(Firulli et al., 2003)
HAND2	B′δ	–	–	(Firulli et al., 2003)
HCP6	B	–	–	(Yeong et al., 2003)
HDAC4	Bα	S298	1–289	(Paroni et al., 2008)
HDAC5	Bα	–	–	(Greco et al., 2011, Joshi et al., 2013)
HDM2	CyG	S166	400–489	(Okamoto et al., 2002)
HOX11	–	–	–	(Kawabe et al., 1997)
HRX	–	–	–	(Adler et al., 1997)
HSF2	–	–	–	(Xing et al., 2007)
HTR1A	–	–	–	(Bauman et al., 2000)
IER3	–	–	–	(Letourneux et al., 2006)
IKBKB	–	S77 &S181	121–179	(Kray et al., 2005, Li et al., 2006)
IKBKG	–	S68	–	(Fu et al., 2003, Palkowitsch et al., 2008)
IL6ST	–	S782	–	(Mitsuhashi et al., 2005)
IQGAP1	–	–	–	(Takahashi & Suzuki, 2006)
IRAK1	–	–	–	(Dobierzewska et al., 2011)
JAK2	–	–	–	(Fuhrer & Yang, 1996)
JNK	–	–	–	(Shanley et al., 2001)
KCNQ2	B′γ	–	E12–14	(Borsotto et al., 2007)
KRT8	–	–	–	(Tao et al., 2006)
KRT18	–	–	–	(Tao et al., 2006)
KSR1	Bα	S392	249–320	(Ory et al., 2003)
LATS2	Bα	–	–	(Woods et al., 2012)
LNX1	–	–	–	(Guo et al., 2012)
MAPK14	–	–	–	(Alvarado-Kristensson & Andersson, 2005)
MASTL (greatwall)	Bα	T194	–	(Hegarat et al., 2014)
MDM2	B′α/CyG	T216	100–280, 400–489	(Okamoto et al., 2002)
MEK3	α4	T193	–	(Prickett & Brautigan, 2007)
MEKK3	Bα, Bδ	S526	–	(Fritz et al., 2006)
MET	–	S985	–	(Hashigasako et al., 2004)
MID1	–	–	–	(Short et al., 2002)
MKK4	–	–	–	(Avdi et al., 2002)
MLH1	Bβ&Bδ	–	–	(Cannavo et al., 2007)
MTOR	Bα	–	–	(Peterson et al., 1999)
MYC (cMYC)	B′α	S62	40–179	(Arnold & Sears, 2006)
NDRG1	Bα	–	–	(Tu et al., 2007)
NEK1	B′α	S109	1–267	(Surpili et al., 2003)
NHE3	B′δ	–	651–839	(Bobulescu et al., 2010)
NKCC1	–	–	–	(Liedtke et al., 2005)
NKD1	PR72	–	–	(Creyghton et al., 2005,2006)
NM23H2	–	–	–	(Chen et al., 2008)
NOD2	B′ε	–	–	(Nimmo et al., 2011)
NOTCH1	Bα	–	–	(Yatim et al., 2012)
NR3A	–	–	–	(Ma & Sucher, 2004)
NRF1	B′γ	–	–	(Satoh et al., 2013)
NTRK1	B′β & B′δ	–	–	(Van Kanegan & Strack, 2009)
OCLN	–	–	–	(Seth et al., 2007)
OSBP	–	–	–	(Wang et al., 2005)
PACS1	–	S278	–	(Scott et al., 2003)
PAK1	–	–	–	(Westphal et al., 1999)
PAK3	–	–	–	(Westphal et al., 1999)
PDE4D/AKAP1	B′δ	–	2083–2319	(Dodge-Kafka et al., 2010)
PER3	–	–	–	(Sathyanarayanan et al., 2004)
PIM1	B′β	–	70–139	(Ma et al., 2007)
PIN1	B′β	–	–	(Huang et al., 2001, Michniewicz et al., 2007)
PKR	B′α	B′α	B′α	(Xu & Williams, 2000)
POLA2	–	–	–	(Dehde et al., 2001)
PPFIA1	B′δ	–	–	(Rual et al., 2005)
PRKAR1A	–	–	–	(Ahn et al., 2007a)
PTPN14	–	–	–	(Wang et al., 2012)
PTTG1 (Securin)	–	–	–	(Gil-Bernabe et al., 2006)
PXN (paxillin)	B′γ1/2	–	–	(Ito et al., 2000)
RAF1	Bα/δ	S259	–	(Adams et al., 2005)
RALA	Aβ	S183, S184	–	(Sablina et al., 2007)
RB1	PR70	T826	792–928	(Lees et al., 1991, Magenta et al., 2008)
RBL1 (p107)	PR59	Mult.	–	(Voorhoeve et al., 1999)
REC8	B′-sgo	Mult.	–	(Ishiguro et al., 2010)
RELA	A	S536	1–155, 354–551	(Fuhrer & Yang, 1996, Li et al., 2006, Yang et al., 2001)
REV1	Bα& Bδ	–	–	(Naji et al., 2012)
RHEB	–	–	–	(Lee et al., 2007)
RHOB	–	–	–	(Lee et al., 2007)
RPS6KB1	–	–	–	(Westphal et al., 1999)
RRAS	–	–	–	(Lee et al., 2007)
RRN3	Bα	S44	–	(Mayer et al., 2004)
RSA1 & RSA2	–	–	–	(Schlaitz et al., 2007)
RUNX2	–	–	–	(Rajgopal et al., 2007)
SET	–	–	–	(Li et al., 1996)
SG2NA	–	–	–	(Moreno et al., 2000)
SHC	–	Y317	–	(Ugi et al., 2002)
SLC6A2	–	–	–	(Sung et al., 2005)
SMAD3	–	–	1–232	(Heikkinen et al., 2010)
SMAD9	B′ε	–	–	(Colland et al., 2004)
SMURF1	Bδ	–	–	(Xie et al., 2013)
SOX2	B′γ	–	–	(Cox et al., 2013)
SP1	–	T739	–	(Chuang et al., 2012)
SPHK1	B′α	S225	451–470	(Pitman et al., 2011)
SPRY1	A	S112, S115	50–60	(Lao et al., 2007)
SRC	Bγ	S12	–	(Eichhorn et al., 2007)
STAT5	–	–	–	(Yokoyama et al., 2001)
STE20	–	–	–	(Liedtke et al., 2005)
STK24	B‴	T178, T182	–	(Gordon et al., 2011)
SUMO1	–	–	–	(Grant, 2010)
TAU	Bα	Mult.	197–259, 265–328	(Xu et al., 2008)
TAX	–	–	–	(Fu et al., 2003)
TBC1D3	B′γ	S6K	–	(Wainszelbaum et al., 2012)
TCEAL1	Bα & Bδ	–	–	(Sowa et al., 2009)
TGFBR1	Bα	–	–	(Griswold-Prenner et al., 1998)
TH	B′β	S19, S31, S40	R37 & R38	(Saraf et al., 2010)
TIP	–	–	–	(McConnell et al., 2007)
TOM22	Bβ	–	–	(Dagda et al., 2005)
TOP1	Bβ	–	–	(Trzcinska et al., 2002)
TP53 (p53)	–, B′γ1/3	S37, T55	–	(Dohoney et al., 2004, Li et al., 2007)
TRAF2	B′γ	T117	272–501	(Li et al., 2006)
TSC2	–	–	–	(Lee et al., 2007)
TTP	–	–	–	(Sun et al., 2007)
UBD	–	–	–	(Aichem et al., 2012)
UBR5	Bγ	–	–	(Chen et al., 2013)
UPF1	–	–	–	(Ohnishi et al., 2003)
VIM	Bα	–	–	(Turowski et al., 1999)
VPU [HIV]	B′ε	–	–	(Jager et al., 2012)
ZRANB1	B‴	–	–	(Tran et al., 2013)

The first row is the abbreviated interacting protein, the second is B subunit if known, the third is dephosphorylation site if known, the fourth is interacting boundary if known and the last row indicates the reference to the work documenting the interaction. Abbreviations were used based on Biogrid entries using Uniprot naming rules. Historical/common names are given in parenthesis where standard abbreviations are not commonly used or not easily interpretable. All proteins mentioned are human, with the exception of important human viral proteins, which have virus names indicated in [brackets].