Table 3.
Impact of lifestyle or therapeutic interventions on the circulating levels of miRNAs in blood of T2DM, obese or pre-diabetic patients [27,28,37,39,52].
| Micro RNAs | Obese vs. controls | Pre-diabetes vs. controls | T2DM vs. controls | Interventions | |||||
|---|---|---|---|---|---|---|---|---|---|
| No. of studies | Regulations | No. of studies | Regulations | No. of studies | Regulations | Physical Activity | Metformin | Bariatric surgery | |
| miR-146a | 1 | + | 2 | + | +(2), (6) | +(3) | |||
| 1 | − | −(7) | |||||||
| miR-142-3p | 2 | + | 1 | − | +(4) | −(3) | |||
| miR-222 | 2 | + | 1 | − | 2 | + | +(2) | −(4) | |
| miR-125b | 2 | − | 1 | + | |||||
| 1 | − | −(3) | |||||||
| miR-140-5p | 2 | + | 1 | + | −(4) | −(3) | |||
| miR-21 | 2 | − | 1 | + | |||||
| 2 | − | +(2) | +(3) | ||||||
| miR-221 | 2 | − | 1 | + | 1 | + | +(2) | +(3) | |
| −(7) | |||||||||
| miR-126 | 1 | + | 1 1 |
+ − |
2 | + | +(7), (6) | ||
| 4 | − | ||||||||
| miR-423-5p | 1 1 |
+ − |
1 | − | 1 | − | +(3) | ||
| miR-130b | 1 1 |
+ − |
1 | + | +(3) | ||||
| miR-192 | 1 | + | −(5) | +(4) | |||||
| miR-193b | 1 | − | −(5) | ||||||