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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Cell Biochem Biophys. 2016 Jun;74(2):263–276. doi: 10.1007/s12013-015-0715-4

FIGURE 2.

FIGURE 2

Functionally expression of Kv1 channels in SMA. A. Time course of inhibition of whole cell Kv current by correolide (10 μmol/L) at +40mV from a holding potential of −80 mV (1 sec duration voltage steps at 30 sec intervals) in the presence of 100 nmol/L IbTx and 1μmol/L nifedipine. Traces on the left show currents before and 15 min after correolide addition. B. Summary of whole cell Kv current-voltage relations before and after the addition of correolide in the presence of IbTx and nifedipine recorded from a holding potential of −80 mV (with 10 mV, 1 sec steps at 20 sec intervals). Representative families of currents are shown on the left before (•) and with correolide (○). Symbols are mean values and vertical bars are ± 1 SEM (n=8). Horizontal and vertical calibration bars in A and B represent 200 pA and 200 msec, respectively. C. Effect of 10 μmol/L correolide (arrow) on wall stress (% of KCl) of an SMA segment precontracted with 100 nmol/L phenylephrine. Horizontal bar represents 2 min.