Table 2.
List of pathways predicted to be targeted by LPS responsive miRNAs. Only top 15 pathways are mentioned.
| A. Predicted pathways of Mφ miRNAs responsive to 1ng/ml E. coli LPS challenged for 1 h. | |||
|---|---|---|---|
| KEGG pathway | p-value | #genes | #miRNAs |
| Adherens junction | 9.68E-12 | 59 | 30 |
| Cell cycle | 6.11E-06 | 82 | 31 |
| TGF-beta signaling pathway | 6.67E-05 | 51 | 30 |
| ErbB signaling pathway | 0.000115 | 59 | 28 |
| Endocytosis | 0.000192 | 123 | 31 |
| Focal adhesion | 0.000192 | 129 | 32 |
| p53 signaling pathway | 0.000258 | 50 | 27 |
| Rap1 signaling pathway | 0.000259 | 127 | 30 |
| PI3K-Akt signaling pathway | 0.000521 | 198 | 31 |
| Regulation of actin cytoskeleton | 0.002879 | 124 | 29 |
| mTOR signaling pathway | 0.003035 | 41 | 27 |
| AMPK signaling pathway | 0.003339 | 78 | 29 |
| ECM-receptor interaction | 0.006131 | 46 | 28 |
| Fc gamma R-mediated phagocytosis | 0.035122 | 55 | 25 |
| Ras signaling pathway | 0.035122 | 123 | 30 |
| B. Predicted pathways of Mφ miRNAs responsive to 1ng/ml E. coli LPS challenged for 8 h. | |||
|---|---|---|---|
| KEGG pathway | p-value | #genes | #miRNAs |
| ErbB signaling pathway | 5.59E-06 | 63 | 32 |
| TGF-beta signaling pathway | 5.74E-06 | 53 | 31 |
| Endocytosis | 2.01E-05 | 130 | 32 |
| Ras signaling pathway | 0.000149 | 133 | 35 |
| MAPK signaling pathway | 0.000745 | 151 | 37 |
| Wnt signaling pathway | 0.001299 | 86 | 33 |
| Regulation of actin cytoskeleton | 0.002783 | 125 | 32 |
| Rap1 signaling pathway | 0.002783 | 124 | 34 |
| Adherens junction | 0.014892 | 47 | 31 |
| Focal adhesion | 0.014892 | 117 | 33 |
| cGMP-PKG signaling pathway | 0.027851 | 93 | 34 |
| AMPK signaling pathway | 0.027851 | 70 | 31 |
| PI3K-Akt signaling pathway | 0.027851 | 182 | 34 |
| SNARE interactions in vesicular transport | 0.029446 | 21 | 22 |
| p53 signaling pathway | 0.039423 | 42 | 26 |
| C. Predicted pathways of Mφ miRNAs responsive to 10 ng/ml E. coli LPS challenged for 1 h. | |||
|---|---|---|---|
| KEGG pathway | p-value | #genes | #miRNAs |
| AMPK signaling pathway | 7.67E-05 | 42 | 10 |
| mTOR signaling pathway | 0.000919 | 24 | 10 |
| Phosphatidylinositol signaling system | 0.001834 | 24 | 9 |
| TGF-beta signaling pathway | 0.008479 | 23 | 10 |
| N-Glycan biosynthesis | 0.005766 | 12 | 8 |
| Adipocytokine signaling pathway | 0.019586 | 22 | 9 |
| mRNA surveillance pathway | 0.020065 | 28 | 11 |
| RNA degradation | 0.036259 | 27 | 10 |
| Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
0.03644 | 9 | 6 |
| Wnt signaling pathway | 0.03644 | 39 | 11 |
| Gap junction | 0.037595 | 21 | 11 |
| cGMP-PKG signaling pathway | 0.046164 | 44 | 10 |
| Sphingolipid signaling pathway | 0.048088 | 31 | 10 |
| Glycosaminoglycan biosynthesis - keratan sulfate |
0.048206 | 4 | 3 |
| D. Predicted pathways of Mφ miRNAs responsive to 10 ng/ml E. coli LPS challenged for 8 h. | |||
|---|---|---|---|
| KEGG pathway | p-value | #genes | #miRNAs |
| ErbB signaling pathway | 1.35E-07 | 73 | 44 |
| ECM-receptor interaction | 4.50E-06 | 55 | 39 |
| Ras signaling pathway | 9.94E-06 | 154 | 49 |
| Focal adhesion | 2.26E-05 | 148 | 48 |
| Endocytosis | 6.10E-05 | 147 | 47 |
| TGF-beta signaling pathway | 0.000179 | 55 | 38 |
| Mucin type O-Glycan biosynthesis | 0.000251 | 20 | 23 |
| Rap1 signaling pathway | 0.000202 | 145 | 48 |
| Adherens junction | 0.002025 | 56 | 43 |
| Wnt signaling pathway | 0.000226 | 100 | 46 |
| Viral carcinogenesis | 0.001341 | 118 | 47 |
| Phosphatidylinositol signaling system | 0.002201 | 56 | 43 |
| Bacterial invasion of epithelial cells | 0.00222 | 56 | 39 |
| PI3K-Akt signaling pathway | 0.002786 | 217 | 48 |
| MAPK signaling pathway | 0.002989 | 169 | 50 |