Table 2. Hot spot list from PAS-A dimer models, with related scores from the PPI prediction tools herein adopted.

PASA.4F3L				PASA.4M4X
Residue	Robetta	HotPoint	KFC2-A	Residue	Robetta	HotPoint	KFC2-A
AhR:L116	1.26	26.53	0.73	AhR:L110	0.51	32.94	-0.34
AhR:L117	0.68	39.46	0.01	AhR:E112	0.72	9.65	0.19
AhR:A119	0.00	12.33	0.10	AhR:F115	2.53	17.12	-0.30
AhR:L120	1.97	39.34	1.35	AhR:L116	2.41	28.67	0.71
AhR:R236	0.38	16.35	0.14	AhR:L117	0.44	41.45	0.80
AhR:F260	0.48	25.43	0.03	AhR:L120	1.40	33.14	-0.01
AhR:I262	0.95	43.23	1.13	AhR:V124	0.53	38.39	0.17
ARNT:L159	0.81	37.38	-1.12	AhR:L240	na	28.51	-2.25
ARNT:E163	-0.45	11.28	0.74	AhR:F260	2.21	27.04	1.20
ARNT:L164	0.52	24.70	-0.51	AhR:I262	0.54	25.90	-1.48
ARNT:L167	1.89	38.70	1.13	ARNT:D161	-0.05	13.08	0.54
ARNT:I168	0.81	39.90	0.54	ARNT:L164	0.85	16.13	0.38
ARNT:A171	0.00	25.54	-0.07	ARNT:I168	2.18	23.52	0.81
ARNT:L176	0.26	29.65	-1.90	ARNT:L169	0.73	38.99	-0.01
ARNT:Y311	2.33	14.40	-0.34	ARNT:L176	0.48	48.69	-0.99
ARNT:I340	0.98	30.43	0.42	ARNT:V338	0.54	28.24	-0.44
				ARNT:A339	na	22.49	-1.02
				ARNT:I340	0.92	25.74	-0.80

na: residue not predicted as hot spot for the specific method

Residues highlighted in bold mostly contribute to the dimer stabilization according to the scores proposed by all methods