Table 2. EZH2 increased cholesterol levels in THP-1-derived foam cells via DNA methylation.
control | 5-Aza-dC | EZH2 | 5-Aza-dC+EZH2 | |
---|---|---|---|---|
TC (mg/g protein) | 503±28 | 391±32* | 594±37# | 508±29 |
FC (mg/g protein) | 190±27 | 138±31* | 242±24# | 191±33 |
CE (mg/g protein) | 314±32 | 174±26* | 454±35# | 312±32 |
CE/TC (%) | 61.9 | 44.5 | 76.4 | 61.4 |
TC: total cholesterol, FC: free cholesterol, CE: cholesterol ester.
*: P<0.05 vs. control
#: P<0.05 vs. 5-Aza-dC+EZH2.