Table 3. EZH2 increased cholesterol levels in RAW264.7 macrophage-derived foam cells via DNA methylation.
control | 5-Aza-dC | EZH2 | 5-Aza-dC+EZH2 | |
---|---|---|---|---|
TC (mg/g protein) | 506±26 | 384±37* | 587±32# | 509±28 |
FC (mg/g protein) | 193±31 | 126±33* | 251±24# | 195±33 |
CE (mg/g protein) | 309±30 | 168±31* | 449±33# | 314±25 |
CE/TC (%) | 61.1 | 43.8 | 76.5 | 61.7 |
TC: total cholesterol, FC: free cholesterol, CE: cholesterol ester.
*: P<0.05 vs. control
#: P<0.05 vs. 5-Aza-dC+EZH2.