Table 3.
Correlations of ketamine concentrations with post-infusion antidepressant response and with psychotomimetic symptoms during the infusion
| Outcome | |||
|---|---|---|---|
|
| |||
| Sustained (week 8) response |
Psychotomimetic effects (Highest BPRS+ score during infusion) |
||
|
| |||
| CGI-I |
MADRS
change from baseline |
||
|
| |||
| S-ketamine concentration | |||
|
| |||
| 96-hour arm | 0.70* | 0.75* | −0.22 |
| 40-minute arm | 0.11 | 0.17 | −0.49 |
|
| |||
| R-ketamine concentration | |||
|
| |||
| 96-hour arm | 0.70* | 0.75* | −0.22 |
| 40-minute arm | 0.11 | 0.17 | −0.49 |
|
| |||
| S-norketamine concentration | |||
|
| |||
| 96-hour arm | 0.62 | 0.65* | −0.06 |
| 40-minute arm | 0.44 | 0.47 | −0.78* |
|
| |||
| R-norketamine concentration | |||
|
| |||
| 96-hour arm | 0.25 | 0.31 | −0.28 |
| 40-minute arm | 0.17 | 0.19 | −0.77* |
Note: spearman correlations were run. spearman correlation coefficient (ρ) is reported. For CGI-I and MADRS change, a significant positive correlation indicates that higher concentration was associated with higher better response; for BPRS+ change, a significant negative correlation indicates that lower concentration is associated with greater psychotomimetic effects. Ketamine concentrations in the 96-hour arm were steady-state concentrations (average of days 3-5), while concentrations in the 40-minute arm were at the end of the infusion.
*
indicates p<0.05