Table 2.
Comparison of B7 family of costimulatory molecules
| Percent Identity | Chromosome | Expression | Receptor | |||
|---|---|---|---|---|---|---|
| (with CD80 extracellular domain) |
Human | Mouse | Lymphoid | Non-Lymphoid | ||
| B7-1 (CD80) | 100% | 3q13 | 16B | T, B, DC, mo, mφ, mast cells | Rare; podocyte, fibroblast, osteoblast |
CD28, CTLA-4 |
| B7-2 (CD86) | 27% | 3q21 | 16B | T, B, DC, mo, mφ, mast cells | Rare | CD28, CTLA-4 |
|
ICOSL (CD275; B7-H2, B7h, B7RP-1, LICOS) |
27% | 21q22 | 10C1 | T, B, DC, mo, mφ, mast cells | Endothelial, epithelial, fibroblast, osteoblast |
ICOS |
|
PD-L1 (CD274; B7-H1) |
25% | 9q24 | 19B | DC, mo, mφ, mast cells, T, B, NK |
Endothelial, epithelial, fibroblast, MSC, pancreas islet, syncytiotrophoblast, stroma, tumor |
PD-1, B7-1 |
|
PD-L2 (CD273; B7-DC) |
23% | 9q24 | 19B | DC, B, Th2, mo, mφ, mast cells |
Endothelial, lung epithelia, tumor |
PD-1, RGMb |
| B7-H3 (CD276) | 29% | 15q24 | 9A | only mouse: APC; only human: T, NK, DC, mo, mφ |
Rare, epithelial, fibroblast, tumor, osteoblast |
? |
|
B7-H4 (B7x, B7S1, Vtcn) |
21% | 1q13.1 | 3F2.2 | DC, mo, mφ | MSC, stroma, tumor | ? |
|
VISTA (PD-1H, Vsir, DD1a, Dies1, Gi24, SISP1, C10orf54) |
24% | 10q22.1 | 10B4 | T, DC, mo, mφ | Stroma, tumor | ? |
| BTNL2 (BTL-II) | 24% | 6p21.3 | 17B1 | mo, mφ; act. T, B | Intestinal epithelial | ? |
|
HHLA2 (B7-H6, B7-H7) |
10% | 3q13.13 | - | only human: B, mo, mφ | only human: endothelial, epithelial, stroma, syncytiotrophoblast, tumor |
TMIGD2 |