Table 1.
Demographic characteristics, genotype and baseline CES-D scores.
| Total Sample | Women | Men | |
|---|---|---|---|
| N | 365a | 249 | 116 |
| Age (yrs) | 76.79 (4.26) | 76.71 (4.12) | 76.94 (4.56) |
| Race (Caucasian/AA/Other) | 283/63/19 | 190/49/10 | 93/14/9 |
| BDNF Status (Met+/Met−) | 107/255 | 70/178 | 37/77 |
| 5-HTT Status (L+/L−) | 269/78 | 185/52 | 84/26 |
| APOE Status (ε4+/ε4−) | 93/266 | 66/177 | 27/89 |
| Baseline CES-D Scores | |||
| Total Score | 7.29 (6.75) | 7.25 (6.38) | 7.40 (7.52) |
| Depressed Affect | 1.54 (2.43) | 1.66 (2.49) | 1.28 (2.28) |
| Somatic Symptoms | 3.38 (2.93) | 3.31 (2.69) | 3.53 (3.40) |
| Lack of Positive Affect | 2.19 (2.53) | 2.10 (2.40) | 2.38 (2.78) |
| % with CES-D ≥ 16 | 11.2% | 10.4% | 12.9% |
a
Total sample varied across gene: BDNF = 362, 5-HTT = 347, APOE = 359
CES-D = Center for Epidemiologic Studies Depression Scale; AA = African-American; BDNF = brain-derived neurotrophic factor; APOE = apolipoprotein E