Table 2.
Baseline CES-D scores by sex and genotype.
| Total Sample | Women | Men | ||||
|---|---|---|---|---|---|---|
| 5-HTT | L+ | L− | L+ | L− | L+ | L− |
| Total CES-D | 6.97 (6.36) | 8.14 (6.54) | 6.88 (6.40) | 8.71 (6.70) | 7.15 (6.32) | 7.00 (6.16) |
| Depressed Affect | 1.38 (2.27) | 1.90 (2.47) | 1.48 (2.46) | 2.31 (2.70) | 1.15 (1.76) | 1.08 (1.69) |
| Somatic Symptoms | 3.26 (2.86) | 3.58 (2.67) | 3.19 (2.82) | 3.62 (2.39) | 3.40 (2.95) | 3.50 (3.20) |
| Lack of Positive Affect | 2.14 (2.50) | 2.47 (2.66) | 2.02 (2.32) | 2.58 (2.75) | 2.43 (2.83) | 2.27 (2.52) |
| BDNF | Met+ | Met− | Met+ | Met− | Met+ | Met− |
| Total CES-D | 7.68 (6.64) | 7.07 (6.77) | 7.53 (6.33) | 7.16 (6.43) | 7.97 (7.28) | 6.86 (7.56) |
| Depressed Affect | 1.57 (2.10) | 1.51 (2.57) | 1.71 (2.18) | 1.63 (2.62) | 1.30 (1.92) | 1.21 (2.43) |
| Somatic Symptoms | 3.59 (2.94) | 3.28 (2.94) | 3.33 (2.56) | 3.31 (2.75) | 4.08 (3.54) | 3.23 (3.34) |
| Lack of Positive Affect | 2.33 (2.71) | 2.08 (2.38) | 2.27 (2.62) | 2.04 (2.32) | 2.43 (2.92) | 2.18 (2.54) |
| APOE | ε4+ | ε4− | ε4+ | ε4− | ε4+ | ε4− |
| Total CES-D | 7.90 (7.66) | 7.09 (6.46) | 7.94 (8.28) | 7.00 (5.59) | 7.82 (6.03) | 7.27 (7.95) |
| Depressed Affect | 1.89 (2.84) | 1.42 (2.29) | 2.15 (3.17) | 1.48 (2.21) | 1.26 (1.70) | 1.28 (2.44) |
| Somatic Symptoms | 3.68 (3.10) | 3.29 (2.89) | 3.50 (3.12) | 3.25 (2.54) | 4.11 (3.04) | 3.36 (3.50) |
| Lack of Positive Affect | 2.14 (2.71) | 2.19 (2.46) | 2.09 (2.81) | 2.08 (2.22) | 2.26 (2.50) | 2.42 (2.87) |
CES-D = Center for Epidemiologic Studies Depression Scale; BDNF = brain-derived neurotrophic factor; APOE = apolipoprotein E