Table 4.

Joint associations of smoking status and alcohol intake with pancreatitis in the Multiethnic Cohort

Alcohol intake stratified by smoking status at baseline	GS-AP		Non-GS pancreatitis*
	No. Cases	HR**(95% CI)	No. Cases	HR**(95% CI)
	MALE
Never smoker
Non-drinker	60	1.00 (ref.)	85	1.00 (ref.)
≤ 48g daily	75	0.99 (0.69–1.41)	80	0.70 (0.51–0.96)
> 48g daily	2	0.39 (0.09–1.60)	14	1.59 (0.87–2.87)
Past smoker
Non-drinker	118	1.34 (0.97–1.86)	173	1.28 (0.98–1.68)
≤ 48g daily	133	1.08 (0.78–1.48)	162	0.86 (0.65–1.12)
> 48g daily	12	0.76 (0.40–1.42)	32	1.30 (0.85–1.99)
Current smoker
Non-drinker	15	0.79 (0.45–1.41)	50	1.48 (1.03–2.12)
≤ 48g daily	31	0.88 (0.56–1.39)	94	1.54 (1.13–2.09)
> 48g daily	8	1.15 (0.54–2.46)	24	2.06 (1.28–3.30)
	FEMALE
Never smoker
Non-drinker	282	1.00 (ref.)	375	1.00 (ref.)
< 24g daily	67	0.61 (0.46–0.80)	127	0.81 (0.66–1.01)
≥ 24g daily	5	0.62 (0.25–1.51)	8	0.65 (0.30–1.38)
Past smoker
Non-drinker	114	1.06 (0.84–1.34)	218	1.39 (1.16–1.66)
< 24g daily	60	0.86 (0.64–1.15)	99	0.97 (0.77–1.23)
≥ 24g daily	7	0.65 (0.30–1.39)	15	1.04 (0.61–1.76)
Current smoker
Non-drinker	48	1.25 (0.90–1.72)	106	1.88 (1.50–2.37)
< 24g daily	24	0.73 (0.47–1.13)	63	1.32 (0.99–1.75)
≥ 24g daily	4	0.47 (0.17–1.28)	20	1.67 (1.03–2.71)

^*This group includes Non-gallstone AP, RAP and CP.

^**HR adjusted for BMI, diabetes, vigorous activity, and education.

Male: P-value for interaction = 0.4563 for GS-AP group.; P-value for interaction = 0.2203 for Non-GS-AP group.

Female: P-value for interaction = 0.4958 for GS-AP group.; P-value for interaction = 0.7061 for Non-GS-AP group.