Extended Data Figure 8. Locus-to-locus variation observed for the three types of epigenetic domains after normalization based on the observed scaling law over domain length.

a, the normalized volume for domains of active (left), inactive (middle), and repressed (right) chromatin. Normalized volume is defined as the ratio of median volume of the domain to the expected volume calculated from the power-law scaling fits shown in Fig. 1c. Error bars represent 78% confidence intervals, such that there is a less than 5% chance that domains with non-overlapping error bars are not distinct. b, Volcano plots of the relative differences in volume between all pairs of active domains (left), inactive domains (middle) or repressed domains (right), after the normalization shown in (a). Each data point represents one pair of domains with their ratio of the normalized volumes plotted on the x-axis and the p-value of their normalized volume difference plotted on the y-axis. The dashed line is at a p-value of 0.05. All dots above this line represent pairs of domains in which the normalized volume of one domain is statistically distinguishable that of the other domain. c, Standard deviation of the normalized volumes for each domain type. Error-bars represent 95% confidence intervals.