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. 2016 Jun 14;7:234. doi: 10.3389/fimmu.2016.00234

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Copyright © 2016 Simon, Marie, Jouen, Boyer and Martinet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological features of inflammatory myopathies. Pathological features of DM. (A) Perimysial and perivascular inflammatory cell infiltrate. Perifascicular myofiber atrophy (arrow heads). Pathological features of anti-HMGCR NAM. (B) Necrotic (asterisk) and regenerative (arrows) myofibers, sparsely infiltrate pathological features of sIBM. (C) Invaded fibers by inflammatory cells. (D) Rimmed vacuoles. (E) Ragged-red fiber. (F) P62 aggregates. (G) Immunohistochemichal evidence of MHC-I myofibers expression. (H) C5b–9 membrane attack complex in capillaries. Composition of the endomysial inflammatory infiltrate (I) CD4⁺ cells, (J) CD8⁺ cells, (K) CD68⁺ cells, and (L) rare CD20⁺ cells. All features provided by Dr. Jean-Philippe Simon.