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. 2016 Jun 14;7:232. doi: 10.3389/fimmu.2016.00232

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Copyright © 2016 Holtappels, Lemmermann, Podlech, Ebert and Reddehase.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of IDEs on the course of infection in HCT recipients. Following regimen “B” of Figure 6, virus replication in HCT recipients infected with mCMV-Δ4IDE, lacking IDEs (open circles), or mCMV-Δ4IDE-rev, expressing IDEs (filled circles), was quantitated over a period of 20 weeks in the spleen (top), lungs (center), and liver (bottom) during hematopoietic reconstitution. Symbols represent data from individual mice, dashes represent the median values. Virus titers in spleen and lungs refer to the whole organ, the numbers of IHC-detected, infected (IE1⁺) liver cells (mostly hepatocytes) refer to representative 10-mm² areas of liver tissue sections. P-values compare data for mutant virus (open circles) and revertant virus (filled circles) cumulated for the time points that precede the reconstitution of CD8⁺ T cells.