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. 2016 Jun 14;7:232. doi: 10.3389/fimmu.2016.00232

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Copyright © 2016 Holtappels, Lemmermann, Podlech, Ebert and Reddehase.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deletion of IDEs is not associated with global alteration in epitope-recognition patterns. At 6 months after HCT and infection with mCMV-Δ4IDE-rev, expressing IDEs (upper panels), or mCMV-Δ4IDE, lacking IDEs (lower panels), epitope-specific reconstitution of CD8⁺ T cells in the spleen was monitored and quantitated by cytofluorometric intracellular IFN-γ assays of cells responding to sensitization. (Left panels), mCMV genome-wide ORF library screening. (Right panels), screening with synthetic peptides corresponding to known epitopes. Arrows point to ORF library positions of epitopes deleted in mutant virus mCMV-Δ4IDE.