Table 3.

Cytokine gene expression levels and their combinations measured from PPD-stimulated PBMCs to discriminate patients with active TB from LTBI.

Cytokine combination	Positive active TB (n = 25)	Positive LTBI (n = 20)	Sens. (%)	Spec. (%)	AUC (CI 95%)	p
IFN-γ	11	3	44	85	0.598 (0.426–0.770)	0.263
IL-17	8	2	32	90	0.534 (0.363–0.705)	0.698
IL-4	8	2	32	90	0.662 (0.500–0.824)	0.064
IFN-γ + IL-17 + IL-4	12	3	48	85	0.586 (0.414–0.758)	0.326
IFN-γ + IL-17	12	3	48	85	0.551 (0.376–0.726)	0.560
IFN-γ + IL-4	9	3	36	80	0.623 (0.452–0.794)	0.160
IL4 + IL-17	11	3	44	85	0.594 (0.426–0.762)	0.283
IFN-γ or IL-17 or IL-4	16	5	64	75	n/a	n/a
IFN-γ or IL-17	13	4	52	80	n/a	n/a
IFN-γ or IL-4	15	4	60	80	n/a	n/a
IL-17 or IL-4	12	4	48	80	n/a	n/a