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. 2016 Feb 25;5(3):436–452. doi: 10.1002/mbo3.341

Figure 2.

Figure 2

M. marinum persists in C. elegans and causes irreversible pathology. Morphology of C. elegans by light microscopy (A–L) and GFP fluorescent C. elegans by confocal microscopy (M–X) infected for 24 h and recovered on E. coli 48 h postinfection. (A–D) E. coli (OP50) infected nematodes are able to lay eggs and retain their dark pigmentation. (E–H) M. smegmatis (tdTomato)‐infected nematodes undergo reversible retention of eggs and loss of pigmentation during infection, but regain pigmentation and the ability to lay eggs postinfection. (I–L) M. marinum (tdTomato)‐infected nematodes experience irreversible retention of eggs and loss of pigmentation during infection. (L) The arrows indicate “bagging” morphological changes that occur when embryos are hatched in utero.