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Schematic illustrating a putative mechanism underlying chronic inflammatory lung diseases involving Cu-deficiency-induced gene expression disruptions in TNF-α lungs. Tnf-α, tumor necrosis factor-α; Aoc3, amine oxidase, copper containing-3; Lox, lysyl oxidase; Vegf, vascular endothelial growth factor; Fak, focal adhesion kinase; Atp7a, copper-transporting P-type ATPase 7a.
