Table 7.

Parameter ranges (average ± standard deviation) for all simulations (n = 5867), active simulations (n = 4341), latch-up simulations (n = 1077), active/non-Latch-up simulations (n = 3264), physiological simulations (n = 65), and dystonia simulations (n = 65).

Parameter	All	Active	Latch-up
mGluR	8.06 ± 6.44	8.02 ± 6.43	8.04 ± 6.34
RYR	108.54 ± 86.99	109.74 ± 86.74	112.03 ± 86.98
HCN	0.0025 ± 0.0003	0.0026 ± 0.0002	0.0026 ± 0.0002
Naf	0.0809 ± 0.0081	0.0829 ± 0.0074	0.0856 ± 0.0072
Kdr	0.0209 ± 0.0053	0.0202 ± 0.0052	0.0216 ± 0.0054
Ka	0.3000 ± 0.0150	0.2977 ± 0.0147	0.2967 ± 0.0144
Kd	0.0009 ± 0.0002	0.0008 ± 0.0002	0.0008 ± 0.0002
Km	1.002e-05 ± 2.48e-06	1e-05 ± 2.49e-06	1.001e-05 ± 2.51e-06
SK	0.0001 ± 6.163e-05	0.0001 ± 6.18e-05	0.0001 ± 6.296e-05
BK	0.0030 ± 0.0015	0.0030 ± 0.0015	0.0031 ± 0.0015
VGCC	0.0052 ± 0.0035	0.0053 ± 0.0035	0.0051 ± 0.0035
Parameter	Active/Non-Latch-up	Physiological	Dystonia
mGluR	8.02 ± 6.45	8.42 ± 6.54	8.12 ± 5.74
RYR	108.99 ± 86.66	105.1 ± 82.9	116.64 ± 77.11
HCN	0.0026 ± 0.0002	0.0026 ± 0.0002	0.0026 ± 0.0003
Naf	0.0820 ± 0.0073	0.0787 ± 0.0053	0.0879 ± 0.0076
Kdr	0.0198 ± 0.0051	0.0226 ± 0.0041	0.0195 ± 0.0054
Ka	0.2981 ± 0.0148	0.3029 ± 0.0144	0.2992 ± 0.0136
Kd	0.0008 ± 0.0002	0.0008 ± 0.0002	0.0008 ± 0.0002
Km	1e-05 ± 2.48e-06	1.034e-05 ± 2.42e-06	1.021e-05 ± 2.81e-06
SK	0.0001 ± 6.135e-05	0.0001 ± 6.797e-05	0.0001 ± 6.604e-05
BK	0.0030 ± 0.0015	0.0034 ± 0.0013	0.0025 ± 0.0015
VGCC	0.0054 ± 0.0035	0.0058 ± 0.0032	0.0046 ± 0.0031

Plasma membrane ion channel conductance density values are in S/cm². mGluR and RYR density are in arbitrary units used to scale channel conductance.