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. 2016 Jun 14;9:45. doi: 10.3389/fnmol.2016.00045

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Copyright © 2016 McCracken, Gorini, McCracken, Mayfield, Harris and Trudell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GLRA1 homology models based on GluCl showing TM3-4 intra-subunit and TM1-3 inter-subunit distances. (A) The enlarged boxed area of a GLRA1 subunit shows distances between the C-alpha atoms of cysteines substituted at A288 (TM3) and Y406, W407, I409, and Y410 (TM4) within the same subunit were 14.7, 11.6, 15.3, and 14.6 Å, respectively. (B) The enlarged boxed area of two GLRA1 subunits shows distances between the C-alpha and S-S atoms of adjacent subunits (rendered as backbone ribbons in red and purple) were 10.3 and 7.8 Å, respectively.