Table 6.
Univariable and multivariable logistic regression analyses of factors associated with ICU mortality in ARDS patients
| n | Death n (%) |
Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|---|
| OR (95 % CI) | p | aOR (95 % CI) | p | |||
| Age (years) | – | – | 1.02 (1.01–1.03) | <0.0001 | 1.02 (1.00–1.03) | 0.029 |
| Year of inclusion | – | – | 0.89 (0.82–0.95) | <0.001 | – | – |
| Liver cirrhosis | ||||||
| Yes | 44 | 31 (70.5) | 2.69 (1.37–5.31) | 0.004 | 2.62 (1.24–5.54) | 0.012 |
| No | 379 | 178 (47.0) | 1 | 1 | ||
| Immunosuppression | ||||||
| Yes | 100 | 58 (58.0) | 1.57 (1.00–2.47) | 0.050 | 1.83 (1.08–3.11) | 0.024 |
| No | 323 | 151 (46.7) | 1 | 1 | ||
| PaO2/FiO2 ratio (mmHg) | – | – | 0.99 (0.99–0.99) | <0.0001 | 0.99 (0.99–0.99) | <0.0001 |
| SAPS II | – | – | 1.03 (1.02–1.04) | <0.0001 | 1.02 (1.00–1.03) | 0.018 |
| LODS | – | – | 1.19 (1.13–1.25) | <0.0001 | 1.12 (1.05–1.20) | <0.001 |
| Antifungal treatmenta | ||||||
| Yes | 17 | 12 (70.6) | 2.55 (0.88–7.36) | 0.084 | – | – |
| No | 406 | 197 (48.5) | 1 | |||
| Blot et al. algorithm[16] | ||||||
| No Aspergillus spp. colonization | 388 | 188 (48.5) | 1 | – | 1 | – |
| Aspergillus spp. colonization | 18 | 6 (33.3) | 0.53 (0.20–1.45) | 0.22 | 0.64 (0.21–1.99) | 0.44 |
| Putative or proven IPA | 17 | 15 (88.2) | 7.98 (1.80–35.36) | 0.006 | 9.58 (1.97–46.52) | 0.005 |
IPA invasive pulmonary aspergillosis
aAs prescribed for a suspicion of invasive pulmonary aspergillosis; the Hosmer–Lemeshow goodness of fit test showed good calibration of the model (p = 0.28); the area under the curve of the model is 0.78 (0.73–0.82); OR (95 % CI), odds ratio (95 % confidence interval); aOR, adjusted odds ratio