Table 1.
Mutations in KRAS and NRAS for which testing should be performed in patients with colorectal cancer. The exons and codons listed are common to both KRAS and NRAS.
| Exon | Codon | Example Mutations |
|---|---|---|
| 2 | 12 | G12C (c.34G > T) |
| G12R (c.34G > C) | ||
| G12S (c.34G > A) | ||
| G12A (c.35G > C) | ||
| G12D (c.35G > A) | ||
| G12V (c.35G > T) | ||
| 13 | G13D (c.38G > A) | |
| 3 | 59 | A59E (c.176C > A) |
| A59G (c.176C > G) | ||
| A59T (c.175G > A) | ||
| 61 | Q61K (c.181C > A) | |
| Q61L (c.182A > T) | ||
| Q61R (c.182A > G) | ||
| Q61H (c.183A > C) | ||
| Q61H (c.183A > T) | ||
| 4 | 117 | K117N (c.351A > C) |
| 146 | A146P (c.436G > C) | |
| A146T (c.436G > A) | ||
| A146V (c.437C > T) |