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Summary of Activation and Inhibition of p7-Mediated Whole-Cell Currents
| pH50 | nH | I-V-Dependent Zero Crossing/Slope (pA)/(pA/mV) | IC50 (nM) Rimantadine | No. of Cells | IC50 (nM) Amantadine | No. of Cells | |
|---|---|---|---|---|---|---|---|
| p7-1a | 6.2 ± 0.4 | 0.77 ± 0.04 | −5.0 ± 3/1.5 ± 0.1 | 0.7 ± 0.1 | 5 | 0.7 ± 0.1 | 5 |
| p7-2a | 6.0 ± 0.9 | 1.3 ± 0.2 | −3.6 ± 4/1.5 ± 0.1 | 24 ± 4 | 5 | 2402 ± 334 | 5 |
| p7-3a | 6.3 ± 0.9 | 1.0 ± 0.2 | −1.2 ± 7/1.4 ± 0.1 | 1.6 ± 0.6 | 5 | 344 ± 64 | 4 |
| p7-4a | 6.5 ± 1.2 | 1.0 ± 0.2 | −8.3 ± 8/1.6 ± 0.2 | 3.0 ± 0.8 | 4 | 3.2 ± 1.2 | 4 |
