Table 1. A selected list of exon-skipping events associated with IDC patient survival.
| Gene symbol | Ensembl transcript ID (exon number) | SURVIV P-value | Gene function |
|---|---|---|---|
| ATRIP | ENST00000320211 (11) | 2.4e−3 | Encodes a critical component of the DNA damage checkpoint52. |
| BCL2L11 | ENST00000308659 (3) | 2.7e−3 | Induces apoptosis and anoikis9,53. |
| CD74 | ENST00000518757 (7) | 2.3e−4 | Regulates antigen presentation for immune response54. |
| PCBP4 | ENST00000484633 (2) | 1.7e−3 | Induced by p53; suppresses cell proliferation55,56. |
| RAD17 | ENST00000354312 (3) | 1.1e−3 | Required for cell cycle arrest and DNA damage repair57. |
| TLR5 | ENST00000342210 (2) | 1.3e−4 | Activates innate immune response58. |
IDC, invasive ductal carcinoma; SURVIV, Survival analysis of mRNA Isoform Variation.