Table 1.
Baseline characteristics of dogs.
| Variable | Control (n = 20) | PDH (n = 20) |
|---|---|---|
| Age (years) | 11.8 ± 2.9 | 12.2 ± 2.5 |
| Body weight (kg) | 6.3 ± 3.5 | 7.0 ± 3.8 |
| Sex (female : male) | 16 : 4 | 17 : 3 |
| Heart rate (bpm) | 121.2 ± 13.9 | 127.1 ± 20.3 |
| Indirect SBP (mmHg) | 132.8 ± 12.1 | 148.8 ± 13.9∗ |
| Prevalence of hypertension (≥ 160 mmHg) | 5% (1/20) | 35% (7/20)∗ |
| Serum albumin (g/dL) | 3.3 ± 3.0 | 3.4 ± 4.0 |
| Serum creatinine (mg/dL) | 0.9 ± 0.3 | 0.8 ± 0.4 |
| Microalbuminuria (UACR 0.03–0.3) | 25% (5/20) | 30% (6/20) |
| Albuminuria (UACR > 0.3) | 0% (0/20) | 40% (8/20)∗ |
| Pre-ACTH cortisol (μg/dL) | 1.8 ± 0.7 | 4.8 ± 3.0∗ |
| Post-ACTH cortisol (μg/dL) | 10.3 ± 2.1 | 29.3 ± 8.0∗ |
Data are presented as mean ± SD or % (n). ACTH, adrenocorticotropic hormone; PDH, pituitary-dependent hyperadrenocorticism; SBP, systemic blood pressure; UACR, urine albumin to creatinine ratio.
∗ P < 0.05 relative to control.