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. 1992 May 15;89(10):4265–4269. doi: 10.1073/pnas.89.10.4265

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

C A Ross 1, S K Danoff 1, M J Schell 1, S H Snyder 1, A Ullrich 1
PMCID: PMC49062  PMID: 1374893

Abstract

Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned from a mouse placenta cDNA library. All three display strong homology in membrane-spanning domains M7 and M8 to the originally cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting heterogeneity of IP3 action within a single cell.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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