Figure 2.

Kinetic model of the meno presto model. The X_sal state is bound by salicylate, but in this manuscript, salicylate is absent. The X_o state is unbound by an anion. The X_c state is bound by chloride, but the intrinsic voltage-sensor charge is not responsive to the membrane electric field. A slow, multiexponential conformational transition to the X_d state via X_n states enables voltage sensing within the electric field. Depolarization moves the positive sensor charge outward, simultaneously resulting in the compact state, C, which corresponds to cell contraction. Parameters and differential equations are provided in (24).