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. 2016 Jun 14;6:27914. doi: 10.1038/srep27914

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Copyright © 2016, Macmillan Publishers Limited

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(A–E) WISH cells were transfected with the pcDNA3.1-c-fos expression plasmid or an empty vector (control). c-fos mRNA (A) and protein (B) levels increased 48 h after transfection. The up-regulation of c-fos was associated with a significant increase in miR-144(C) and COX2 mRNA (D) and protein (E) levels. (F–J) WISH cells were transfected with c-fos siRNA or with a scrambled siRNA (control). c-fos mRNA (F) and protein (G) levels significantly decreased 48 h after transfection. (H) The decrease in c-fos expression was associated with a significant increase in miR-144 levels. The down-regulation of c-fos was associated with a significant suppression of COX2 mRNA (I) and protein (J) levels. The data are presented as the mean ± SD of the results of three independent experiments. Each experiment was conducted in triplicate. *Statistically significant (P < 0.05) difference compared with the control.