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. 2015 Jan 23;71(7):866–875. doi: 10.1093/gerona/glu238

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© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 4. — Locomotor activity (left panels) and a measure of anxiety (right panels) in control, intermittent feeding (IF), and rapamycin treatment groups of both ages. Regarding absolute levels of locomotor activity (top panel), there was a significant main effect of phase in the young animals (activity decreased in all groups with repeated testing), and a significant interaction in the old animals (decreases in control and IF rats, with no change in rapamycin-treated animals). Regarding the % change in activity (bottom panel), there were significant main effects of age (larger decrease in young rats) and treatment condition (rapamycin> control > IF). For the anxiety absolute measures (top panel), there was a significant interaction with increases in anxiety due to treatment in the young animals. Regarding the % change in anxiety (bottom panel), IF animals spent more time in the margin following treatment compared with control and rapamycin groups at both ages. For the absolute measures, * indicates a significant main effect of phase, and + indicates a difference following a significant interaction. For the relative measures, * indicates a significant main effect of treatment group.