Table 1.

Summary of 5-Week Treatment Effects in Young and Old Rats

	Intermittent Feeding		Rapamycin
	6	25	6	25
Food consumption*,†	↓	↓	↓	↓
Body weight*,†	↓	↓	↓	↓
Lean mass*,†	↓	↓	↑	↑
Fat mass*,†	—	—	—	↓
Lean-to-fat ratio*,†	↓	—	—	↑
Locomotor activity‡	↓	↓	↓	—
Anxiety‡	↑	↑	—	—
Grip strength	—	—	—	—
Leptin*,†	—	—	↓	↓
AMPK*,†	—	↓	—	↓
pAMPK*,†	—	↓	—	↓
Glucose	—	—	—	—

Notes:*Age-related effects described in text.

^†Change relative to control.

^‡Change relative to baseline.