Table 1.

Life-span Data for db/db Mice Fed Rapamycin

	Days Survived Since Diet Start, Males				Days Survived Since Birth, Males
	Control	Rapamycin	∆ Days	% ∆	Control	Rapamycin	∆ Days	% ∆
Mean	309.1 (37.8)	232.3 (28.2)	−76.8	−24.90%	420 (37.7)	351.3 (28.2)	−68.7	−16.40%
50% Mortality	237 (146, 442)	183 (128, 264)	−54	−22.80%	349 (265, 539)	302 (247, 383)	−47	−13.50%
90% Mortality	639 (590, —)	510 (342, —)	−129	−20.20%	758 (709, —)	629 (461, —)	−129	−17.00%
	Days Survived Since Diet Start, Females				Days Survived Since Birth, Females
	Control	Rapamycin	∆ Days	% ∆	Control	Rapamycin	∆ Days	% ∆
Mean	459.8 (37.7)	338.1 (31.3)	−121.7	−26.50%	578.8 (37.7)	439.5 (32.1)	−139.3	−24.10%
50% Mortality	368 (292, 652)	301 (251, 394)	−67	−18.20%	487 (411, 771)	411 (365, 488)	−76	−15.60%
90% Mortality	794 (705, —)	610 (498, —)	−184	−23.20%	913 (824, —)	704 (617, —)	−209	−22.90%
Cox Proportional Hazard Analysis
	Hazard Ratio	p Value (adjusted)
Rapamycin effect in males	1.72	.0496
Females	1.6972	.0496

Note: Standard errors around the means are shown in parentheses; 95% confidence intervals are shown for the quantiles.