Table 3.
Brain Patterns of Associations Between White Matter Hyperintensities and Gait Speed for Participants With Low and High Total Brain Fractional Anisotropy After Adjustment by Age and Gender
| Peak | Cluster Size (mm3) | 1 − p value | MNI Coordinates (mm) | Tracts | ||
|---|---|---|---|---|---|---|
| x | y | z | JHU White Matter Labels and Tractography Atlases | |||
| Participants with low FA | ||||||
| Posterior corona radiata L | 1,115 | .979 | 115 | 98 | 103 | Information processing tracts (superior and posterior corona radiata L, superior longitudinal fasciculus L) |
| Interhemispheric tracts (superior and posterior corona radiata L) | ||||||
| Anterior corona radiata R | 402 | .979 | 66 | 146 | 93 | Information processing tracts (anterior corona radiata R, superior fronto-occipital fasciculus R) |
| Sensory-motor tracts (anterior limb of internal capsule R) | ||||||
| Interhemispheric tracts (genu and body of corpus callosum, anterior corona radiata R) | ||||||
| Superior corona radiata L | 133 | .969 | 112 | 134 | 96 | Information processing tracts (anterior and superior corona radiata L, superior fronto-occipital fasciculus L) |
| Interhemispheric tracts (anterior and superior corona radiata L) | ||||||
| Anterior corona radiata R | 18 | .960 | 64 | 161 | 79 | Information processing tracts (anterior corona radiata R) |
| Anterior corona radiata R | 14 | .962 | 68 | 151 | 77 | Information processing tracts (anterior corona radiata R) |
| Participants with high FA | ||||||
| Inferior longitudinal fasciculus L | 5,732 | .988 | 121 | 124 | 48 | Information processing tracts (anterior corona radiata L, inferior longitudinal fasciculus L, inferior fronto-occipital fasciculus L) |
| Sensory-motor tracts (external capsule L) | ||||||
| Interhemispheric tracts (genu of corpus callosum) | ||||||
| Cingulum L | 117 | .961 | 95 | 150 | 65 | Information processing tract (cingulum L) |
| Genu of corpus callosum | 78 | .961 | 94 | 149 | 73 | Interhemispheric tracts (genu of corpus callosum) |
Notes: FA = fractional anisotropy; MNI = Montreal Neurological Institute.
This table reports the spatial distribution of the associations including the size of the cluster, the corrected 1 − p value for the cluster and the location of the maximum z-statistic in MNI coordinates.