Figure 2. Two hundred and five “hits” identified in cells that resist BCG infection.

(A) Sequence frequencies in uninfected-, BCG^high- and BCG^low- THP1 cells. Each symbol represents one sequence. Red symbols represent 205 sequences that are above the cut off value. (B) Distribution of Z-scores of sequences in BCG^low cells obtained after the third round of selection. Each symbol represents one sequence. Red symbols represent 290 sequences with Z-scores >2. (C) Ratio of frequencies of 205 “hits” between BCG^low- and BCG^high cells. BCG^low cells obtained after the third round of selection were used in this calculation. (D) Correlation of 205 “hit” frequencies measured in BCG^low cells after the second and third rounds of selection.