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. 2015 Jun 9;36(4):327–388. doi: 10.3109/10799893.2015.1015737

Table 6. σR drug binding in tumor tissues and cell lines.

Cell line or tumor tissue σR ligands tested Reference
Non-small-cell lung carcinoma IPAB, haloperidol, DTG (954)
Large-cell-carcinoma (NCI-H1299 and NCI-H838) IPAB, haloperidol, DTG (954)
Lung cancer cell line (NCI-H727) IPAB, haloperidol, PTZ, DTG, (+/−) dextrallorphan (755,953)
Breast ductal carcinoma (T47D) PTZ, DTG, (+/−) dextrallorphan (755,953)
Renal carcinoma DTG (952)
Colon carcinoma DTG (952)
Sarcoma DTG (952)
Brain tumor tissue DTG (1024)
(Nude mouse) neuroblastoma and glioma DTG (1024)
Rat neuroblastoma(NIE-115), rat glioma (c6) PTZ, DTG, (+/−) dextrallorphan (755,953)
U-138MG glioblastomas PTZ, DTG, (+/−) dextrallorphan (755,953)
Breast cancer cell line (MCF-7; T47D; SKBr3) Haloperidol, CB-64D, CB-184, IPAB (103,1025)
Small-cell lung cancer (NCI-H209/N417) IBP, haloperidol (955)
Neuroblastoma [BE(2)]; SK-N-SH) PTZ, DTG, (+/−) dextrallorphan (755,953,1026)
Prostate tumor cells (DU-145) (LnCap) IPAB, PTZ, DTG, (+/−) dextrallorphan (755,953,1025)
Mammary adenocarcinoma (line 66) DTG (1027)
Melanoma (A375) PTZ, DTG, (+/−) dextrallorphan (955)
C6 glioma cells 11C-SA4503 (1028)