Table 5. A description of the top three k-mers found by AdaBoost and their corresponding genomic regions in M. tuberculosis TKK_02_0002, KT-0099, TKK_02_0004 and TKK_03_0024.
| Rank | α-value | k-mers with an identical pattern | Corresponding genes | PATRIC annotation |
|---|---|---|---|---|
| Ethambutol | ||||
| 1 | 0.267 | 1 | fig|1397854.3.peg.744 | DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) |
| 2 | 0.208 | 29 | fig|1400933.3.peg.3985 | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (EC 2.4.2.-) |
| 3 | 0.240 | 1 | fig|1397854.3.peg.3144 | FIG00820705: hypothetical protein |
| Ethionamide | ||||
| 1 | 0.467 | 31 | fig|1295720.3.rna.14 | Small Subunit Ribosomal RNA |
| 2 | 0.292 | 13 | fig|1295720.3.peg.4188 | Partial REP13E12 repeat protein |
| 3 | 0.257 | 8 | intergenic region | Between fig|1295720.3.peg.3517 LSU ribosomal protein L2p (L8e) and fig|1295720.3.peg.3518 LSU ribosomal protein L23p (L23Ae) |
| Isoniazid | ||||
| 1 | 0.982 | 1 | fig|1397854.3.peg.2114 | Catalase (EC 1.11.1.6)/Peroxidase (EC 1.11.1.7) |
| 2 | 0.517 | 3 | fig|1400933.3.peg.1961 | PE-PGRS family protein |
| 3 | 0.244 | 2 | fig|1397854.3.peg.2292 | Polyketide synthase |
| Kanamycin | ||||
| 1 | 0.995 | 31 | fig|1397854.3.rna.19 | Small Subunit Ribosomal RNA |
| 2 | 0.494 | 27 | intergenic region | Between fig|1397854.3.peg.2690, RNA 3′-terminal phosphate cyclase (EC 6.5.1.4) and fig|1397854.3.peg.2691, CBS domain protein |
| 3 | 0.264 | 2 | fig|1397854.3.peg.9 | DNA gyrase subunit A (EC 5.99.1.3) |
| Ofloxacin | ||||
| 1 | 0.471 | 2 | fig|1397854.3.peg.9 | DNA gyrase subunit A (EC 5.99.1.3) |
| 2 | 0.373 | 18 | fig|1397854.3.peg.3738 | PPE family protein |
| 3 | 0.236 | 10 | fig|1397854.3.peg.9 | DNA gyrase subunit A (EC 5.99.1.3) |
| Rifampicin | ||||
| 1 | 0.610 | 1 | fig|1397854.3.peg.744 | DNA-directed RNA polymerase beta subunit (EC 2.7.7.6) |
| 2 | 0.785 | 2 | fig|1397854.3.peg.294 | Nitrate/nitrite transporter |
| 3 | 0.518 | 1 | fig|1397854.3.peg.2114 | Catalase (EC 1.11.1.6)/Peroxidase (EC 1.11.1.7) |
| Streptomycin | ||||
| 1 | 0.386 | 31 | fig|1448395.3.peg.756 | SSU ribosomal protein S12p (S23e) |
| 2 | 0.342 | 3 | fig|1448395.3.peg.6 | DNA gyrase subunit A (EC 5.99.1.3) |
| 3 | 0.200 | 8 | fig|1448395.3.peg.1615 | PE-PGRS family proteinCOX10-CtaB |
Genomes were chosen as examples with exact k-mer matches. The complete list of k-mers is described in the supplementary data file.