Table 1.

Subgrouping and treatment indications for patients with intermediate stage HCC [15]

BCLC Substage	B1	B2	B3	B4
CPT score	5–6–7	5–6	7	8–9
Beyond Milan and within Up-to-7	IN	OUT	OUT	ANY
ECOG (Tumor Related) PS	0	0	0	0–1
PVT	NO	NO	NO	NO
1st option	TACE	TACE or TARE		BSC
Alternative	LT	SOR	Research trials	LT
	TACE + ablation		TACE
			SOR

CPT=Child-Pugh-Turcotte; ECOG=Eastern Cooperative Oncology Group; PS=performance status; PVT=portal vein thrombosis; TARE=transarterial radioembolization; LT=liver transplantation.