Table 3.
Subclassification and treatment strategies of intermediate-stage HCC (Kinki Criteria) [18]
| BCLC Substage | B1 | B2 | B3 | ||
|---|---|---|---|---|---|
| Child-Pugh Score | 5–7 | 5–7 | 8, 9 | ||
| Beyond Milan and within up-to-7 | IN | OUT | ANY | ||
| IN | OUT | ||||
| Subsubstage | B3-a | B3-b | |||
| Concept of Treatment strategy | Curative intent | Noncurative, Palliative | Curative intent if within up-to-7 | Palliative, No treatment | |
| Treatment option | Resection | DEB-TACEa | Transplantation | HAIC | |
| Ablation | HAICb | Ablation | selective DEB-TACE | ||
| Superselective cTACE | SORc | Superselective cTACE | |||
| Alternative | DEB-TACE | cTACE | DEB-TACE | BSC | |
| (large, CP 7) | B-TACE | ||||
| B-TACEd | |||||
B-TACE=balloon-ocduded transarterial chemoembolization.
a
DEB-TACE is recommended for huge tumors that are >6 cm.
b
HAIC is recommended for multiple tumors >6 in total.
c
SOR is recommended for patients with liver function of Child-Pugh score 5 and 6.
d
B-TACE is recommended for fewer tumors.