Table 3.
BCLC Substage | B1 | B2 | B3 | ||
---|---|---|---|---|---|
Child-Pugh Score | 5–7 | 5–7 | 8, 9 | ||
Beyond Milan and within up-to-7 | IN | OUT | ANY | ||
IN | OUT | ||||
Subsubstage | B3-a | B3-b | |||
Concept of Treatment strategy | Curative intent | Noncurative, Palliative | Curative intent if within up-to-7 | Palliative, No treatment | |
Treatment option | Resection | DEB-TACEa | Transplantation | HAIC | |
Ablation | HAICb | Ablation | selective DEB-TACE | ||
Superselective cTACE | SORc | Superselective cTACE | |||
Alternative | DEB-TACE | cTACE | DEB-TACE | BSC | |
(large, CP 7) | B-TACE | ||||
B-TACEd |
B-TACE=balloon-ocduded transarterial chemoembolization.
DEB-TACE is recommended for huge tumors that are >6 cm.
HAIC is recommended for multiple tumors >6 in total.
SOR is recommended for patients with liver function of Child-Pugh score 5 and 6.
B-TACE is recommended for fewer tumors.