Table 2.

Data obtained from the kinetic fit of a 1:1 binding model to the SPR single cycle kinetics sensograms.

cmpd	K d [μM]	k on [m −1 s−1]	k off [s−1]	k off [s−1]×103	t 1/2 [min]	R max
1	47.5	326.1	0.01548	15.48	0.75	18.8
2	1.12	552.6	0.00062	0.62	18.64	94.9
3	18.1	100.9	0.00183	1.83	6.33	93.8
7 b	7.67	169.6	0.00130	1.30	8.88	107.0