Table II.
Enriched GO functions for the differentially-expressed genes.
| Gene regulation | GO term | Description | Gene number | Gene symbol | P-value |
|---|---|---|---|---|---|
| Upregulated genes | GO:0042158 | Lipoprotein biosynthetic process | 5 | ABCA1, LCAT, MTTP, PIGF, PPM1B | 1.30×10−4 |
| GO:0007204 | Elevation of cytosolic calcium ion concentration | 5 | CCR1, CXCR3, GALR2, LIME1, TPCN2 | 1.34×10−2 | |
| GO:0022617 | Extracellular matrix disassembly | 4 | CTSK, KLKB1, MMP3, MMP7 | 4.50×10−3 | |
| GO:0051592 | Response to calcium ion | 4 | ANXA11, KCNMB1, MTTP, SPARC | 5.28×10−3 | |
| GO:0030574 | Collagen catabolic process | 3 | CTSK, MMP3, MMP7 | 1.86×10−2 | |
| GO:0010875 | Positive regulation of cholesterol efflux | 2 | ABCA1, ABCG1 | 3.07×10−3 | |
| GO:1902166 | Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2 | CD44, MUC1 | 3.07×10−3 | |
| GO:003443 | Cholesterol esterification | 2 | ABCG1, LCAT | 3.67×10−3 | |
| GO:0034616 | Response to laminar fluid shear stress | 2 | ABCA1, TGFB3 | 3.67×10−3 | |
| GO:0034375 | High-density lipoprotein particle remodeling | 2 | ABCG1, LCAT | 5.01×10−3 | |
| Downregulated genes | GO:0006469 | Negative regulation of protein kinase activity | 8 | CDKN1A, DUSP1, DUSP10, DUSP4, DVL1, GADD45G, PDPK1, SOCS1 | 4.97×10−5 |
| GO:0030308 | Negative regulation of cell growth | 7 | BCL2, CDKN1A, HSPA1B, PML, PPP1R9B, SCGB3A1, SERTAD3 | 1.39×10−4 | |
| GO:0051403 | Stress-activated MAPK cascade | 7 | AKT2, CCM2, CDC42EP5, DUSP10, DUSP4, FOS, MAP2K3 | 1.73×10−3 | |
| GO:0046777 | Protein autophosphorylation | 6 | CAMKK2, ERN1, PDGFA, PDPK1, PIM3, STK24 | 3.65×10−3 | |
| GO:0006986 | Response to unfolded protein | 5 | DNAJB1, ERN1, HSPA1B, HSPA2, HSPA6 | 4.61×10−3 | |
| GO:0008286 | Insulin receptor signaling pathway | 5 | AKT2, EIF4EBP1, PDPK1, SOCS1, TCIRG1 | 1.19×10−2 | |
| GO:0048146 | Positive regulation of fibroblast proliferation | 3 | CDKN1A, PDGFA, S100A6 | 4.29×10−3 | |
| GO:0045069 | Regulation of viral genome replication | 3 | BCL2, OASL, PPID | 9.26×10−3 | |
| GO:0030833 | Regulation of actin filament polymerization | 3 | ARPC1B, CDC42EP5, PFN2 | 3.98×10−2 | |
| GO:0008295 | Spermidine biosynthetic process | 2 | AGMAT, AMD1 | 3.78×10−4 |
GO, Gene Ontology; MAPK, mitogen-activated protein kinases.