Table III.
Enriched KEGG pathways for the differentially-expressed genes.
| Gene regulation | Term | Description | Gene number | Gene symbol | P-value |
|---|---|---|---|---|---|
| Upregulated genes | 30 | Pentose phosphate pathway | 2 | H6PD, RBKS | 2.43×10−2 |
| 4640 | Hematopoietic cell lineage | 3 | CD1C, CD44, CR1 | 4.46×10−2 | |
| 5323 | Rheumatoid arthritis | 3 | CTSK, MMP3, TGFB3 | 4.84×10−2 | |
| Downregulated genes | 4010 | MAPK signaling pathway | 13 | AKT2, DUSP1, DUSP10, DUSP4, FOS, GADD45G, GNA12, HSPA1A, HSPA1B, HSPA2, HSPA6, MAP2K3, PDGFA | 3.77×10−6 |
| 5200 | Pathways in cancer | 9 | AKT2, BCL2, CDKN1A, DVL1, FOS, PDGFA, PML, TCF7, VHL | 7.47×10−3 | |
| 5145 | Toxoplasmosis | 8 | AKT2, BCL2, HSPA1A, HSPA1B, HSPA2, HSPA6, MAP2K3, SOCS1 | 7.24×10−5 | |
| 4141 | Protein processing in endoplasmic reticulum | 8 | BCL2, DNAJB1, ERN1, HSPA1A, HSPA1B, HSPA2, HSPA6, HSPBP1 | 3.41×10−4 | |
| 5215 | Prostate cancer | 6 | AKT2, BCL2, CDKN1A, PDGFA, PDPK1, TCF7 | 3.48×10−4 | |
| 4910 | Insulin signaling pathway | 6 | AKT2, EIF4EBP1, HK1, PDPK1, PPP1R3C, SOCS1 | 3.42×10−3 | |
| 4144 | Endocytosis | 6 | CHMP6, HSPA1A, HSPA1B, HSPA2, HSPA6, PML | 2.01×10−2 | |
| 3040 | Spliceosome | 5 | HSPA1A, HSPA1B, HSPA2, HSPA6, PRPF6 | 1.13×10−2 | |
| 5221 | Acute myeloid leukemia | 4 | AKT2, EIF4EBP1, PML, TCF7 | 3.11×10−3 | |
| 5210 | Colorectal cancer | 4 | AKT2, BCL2, FOS, TCF7 | 4.22×10−3 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinases.