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Pairwise concordance between methods of KRAS mutation detection.
| Method | Scorpion-ARMS | Pyrosequencing | Luminex xMAP | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Direct sequencing | W | M | NE | W | M | NE | W | M | NE |
| W | 39 | 1 | 0 | 39 | 1 | 0 | 37 | 3 | 0 |
| M | 0 | 28 | 0 | 0 | 28 | 0 | 0 | 28 | 0 |
| NE | 3 | 0 | 2 | 2 | 0 | 3 | 1 | 0 | 4 |
| κ=0.89672 | κ=0.92347 | κ=0.90004 | |||||||
| Scorpion-ARMS | |||||||||
| W | 41 | 0 | 1 | 37 | 2 | 3 | |||
| M | 0 | 29 | 0 | 0 | 29 | 0 | |||
| NE | 0 | 0 | 2 | 1 | 0 | 1 | |||
| κ=0.97355 | κ=0.84502 | ||||||||
| Pyrosequencing | |||||||||
| W | 37 | 2 | 2 | ||||||
| M | 0 | 29 | 0 | ||||||
| NE | 1 | 0 | 2 | ||||||
| κ=0.87238 | |||||||||
KRAS, Kirsten rat sarcoma viral oncogene homolog; W, wild-type KRAS; M, mutated KRAS; NE, not evaluated.
