Table IV.

Detection capability of each analytical method for undetectable cases.

Case	Direct sequencing	Scorpion-ARMS	Pyrosequencing	Luminex xMAP	DNA (ng/µl) without MD	DNA (ng/µl) with MD	ORR	PFS (days)	OS (days)
1	NE	Wild	Wild	NE	95.6	100.5	SD	83	157
2	NE	Wild	NE	NE	39.0	57.7	SD	383	740
3	NE	NE	NE	NE	26.6	56.2	PR	116	317
4	NE	NE	NE	Wild	2.1	4.3	SD	61	147
5	NE	Wild	Wild	NE	93.5	126.5	PD	17	95

NE, not evaluated; Wild, wild-type KRAS; ORR, objective response rate; PFS, progression-free survival; OS, overall survival; PR, partial response; SD, stable disease; PD, progression disease; MD, manual microdissection.