Table V.
Case | Direct sequencing | Scorpion-ARMS | Pyro-sequencing | Luminex-xMAP | Mutation site | DNA (ng/µl) without MD | DNA (ng/µl) with MD | ORR | PFS (days) | OS (days) |
---|---|---|---|---|---|---|---|---|---|---|
1 | Wild | Wild | Wild | Mutant | G12D | 78.3 | 68.7 | PR | 287 | 344 |
2 | Wild | Wild | Wild | Mutant | G12S | 217.5 | 215.5 | SD | 108 | 208 |
3 | Wild | Mutanta | Mutanta | Mutanta | G12C | 138.7 | 182.5 | PD | 42 | 90 |
All cases had KRAS G12C mutation. Wild, wild-type KRAS; mutant, mutated KRAS; ORR, objective response rate; PFS, progression-free survival; OS, overall survival; PR, partial response; SD, stable disease; PD, progression disease; MD, manual microdissection.