Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Gefitinib mediates autophagy and apoptosis of A549 cells via suppression of the PI3K/AKT/mTOR pathway. Western blot analysis showing reduced protein expression of PI3K, AKT, pAKT, mTOR and p-mTOR in A549 cells following gefitinib treatment, however, no differences in protein expression were identified in A549-GR cells. GR, gefitinib-resistant; PI3K, phosphatidylinositol 3-kinase; AKT, protein kinase B; mTOR, mammalian target of rapamycin; p, phosphorylated.
